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KMID : 0376219740110031025
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Chonnam Medical Journal
1974 Volume.11 No. 3 p.1025 ~ p.1035
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Experimental Studies on Reticuloendothelial Function in Rats as Affected by Anesthesia
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Abstract
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The effects of anesthesia on the function of RES were studied in rats by the, carbon clearance method, employing commonly used anesthetic agents.
The phagocytic activity after anesthesia with methoxyflurane began to decline in 3 hours and was depressed most markedly 2 days following anesthesia. Thereafter, the activity returned to almost normal in 7 days and increased markedly 14 days after anesthesia.
In ether anesthesia, moderate decline in the activity began to occur in 3 hours and continued up to 7 days with marked increase at 14 days after anesthesia.
In halothane, anesthesia, the activity declined moderately in 3 hours, and began to increase after 2 days, reaching a maximum 7 days after anesthesia.
Ketalar anesthesia caused an early decline in 3 hours and a most marked increase in the activity in 2 days after anesthesia. The activity was still increased greater: than normal after 7 days, though it had decreased from the peak noted at 2 days.
Thiopental and epontol anesthesia caused an increase in 3 hours, a depression, in 2 days and moderate increase at 7 days.
Three types. of the phagocytic response to anesthesia could be recognized according to the anesthetic agents used the methoxyflurane and ether group, the halothane and ketalar group, and the thiopental and epontol group.
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